Colin Singleton, a child prodigy who loves anagrams and facts, has just been dumped by his 19th girlfriend—all of whom were named Katherine. Heartbroken and feeling like a 'washed-up' genius, his best friend Hassan convinces him to go on a road trip to forget his troubles. They end up in Gutshot, Tennessee, where they meet Lindsey Lee Wells and get caught up in a summer adventure involving a dead factory owner, a wild boar hunt, and Colin's desperate attempt to create a mathematical formula that can predict the future of any relationship. Through this journey, Colin learns that life's most important stories can't be captured by a theorem, and that you don't need to be a prodigy to matter.